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Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds
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Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds Hardcover - 1989 - 1st Edition

by Harry P. Illing


From the publisher

This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.

First line

The study of the metabolism of foreign compounds in mammalian systems began as long ago as the 19th century with the discovery of pathways of conjugation and aryl and alkyl hydroxylation.

Details

  • Title Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds
  • Author Harry P. Illing
  • Binding Hardcover
  • Edition number 1st
  • Edition 1
  • Pages 232
  • Volumes 1
  • Language ENG
  • Publisher CRC Press, Boca Raton, Florida, U.S.A.
  • Date February 28, 1989
  • Illustrated Yes
  • Features Bibliography, Illustrated, Index
  • ISBN 9780849361630 / 084936163X
  • Library of Congress Catalog Number 88010571
  • Dewey Decimal Code 599.019

About the author

H. Paul A. Illing, Ph.D., F.I.Biol., F.R.S.C., Dip.R.C. Path., is Head of Toxicology in the Medical Division of the Health and Safety Executive, Merseyside, U.K., Dr. Illing studied at Queens College, Dundee (from 1967, University of Dundee) and graduated B.Sc. (St. Andrews) in 1969 and Ph.D. (Dundee) in 1972. Following a period at the University of Mainz (West Germany) as aWellcome Trust/DFG Fellow, Dr. Illing was a Scientist and Senior Scientist in Drug Metabolism and Pharmacokinetics at Hoechst Pharmaceutical Research Laboratories, Milton Keynes, U.K. from 1974 to 1982. Since 1982 he has been at the Health and Safety Executive where he was appointed to his present position in 1986., Dr. Illing is a Fellow of the Institute of Biology and of the Royal Society of Chemistry and holds the Diploma in Toxicology of the Royal College of Pathologists. He is a member of the Biochemical Society, the British Toxicology Society, and the U.K. Environmental Mutagenicity Society., Dr. Illing's interests include methods for studying foreign compound metabolism and the role of such studies in understanding the biological effects of chemicals.

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Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds
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Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds

by Harry P.A. Illing

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Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds
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Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds

by Harry P.A. Illing

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CRC Pr I Llc, 1989. Hardcover. New. 1st edition. 232 pages. 10.30x7.30x0.70 inches.
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